Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity

The catalysis of reactions involving fluoropyruvate as donor by N-acetyl neuraminic acid lyase (NAL) variants was investigated. Under kinetic control, the wild-type enzyme catalysed the reaction between fluoropyruvate and N-acetyl mannosamine to give a 90 : 10 ratio of the (3R,4R)- and (3S,4R)-confi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Stockwell, Jennifer, Daniels, Adam D., Windle, Claire L., Harman, Thomas A., Woodhall, Thomas, Lebl, Tomas, Trinh, Chi H., Mulholland, Keith, Pearson, Arwen R., Berry, Alan, Nelson, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717870/
https://ncbi.nlm.nih.gov/pubmed/26537532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob02037a
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados