Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

The substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched from the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation generating N-alkylcarboxamide analogues of N-acetylneuraminic acid. This...

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Detalhes bibliográficos
Main Authors: Campeotto, Ivan, Bolt, Amanda H., Harman, Thomas A., Dennis, Caitriona, Trinh, Chi H., Phillips, Simon E.V., Nelson, Adam, Pearson, Arwen R., Berry, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014015/
https://ncbi.nlm.nih.gov/pubmed/20826162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.08.008
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