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p97/VCP promotes Cullin‐RING‐ubiquitin‐ligase/proteasome‐dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα

Cullin‐RING‐ubiquitin‐ligase (CRL)‐dependent ubiquitination of the nuclear factor kappa B (NF‐κB) inhibitor IκBα and its subsequent degradation by the proteasome usually precede NF‐κB/RelA nuclear activity. Through removal of the CRL‐activating modification of their cullin subunit with the ubiquitin...

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Pubblicato in:J Cell Mol Med
Autori principali: Schweitzer, Katrin, Pralow, Alexander, Naumann, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717852/
https://ncbi.nlm.nih.gov/pubmed/26463447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12702
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