Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remain unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine ho...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Lin, Jieru E., Colon-Gonzalez, Francheska, Blomain, Erik, Kim, Gilbert W., Aing, Amanda, Stoecker, Brian, Rock, Justin, Snook, Adam E., Zhan, Tingting, Hyslop, Terry M., Tomczak, Michal, Blumberg, Richard S., Waldman, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717834/
https://ncbi.nlm.nih.gov/pubmed/26773096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1467-T
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