Obesity-induced colorectal cancer is driven by caloric silencing of the guanylin-GUCY2C paracrine signaling axis

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remain unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine ho...

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Pubblicato in:Cancer Res
Autori principali: Lin, Jieru E., Colon-Gonzalez, Francheska, Blomain, Erik, Kim, Gilbert W., Aing, Amanda, Stoecker, Brian, Rock, Justin, Snook, Adam E., Zhan, Tingting, Hyslop, Terry M., Tomczak, Michal, Blumberg, Richard S., Waldman, Scott A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717834/
https://ncbi.nlm.nih.gov/pubmed/26773096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1467-T
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