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Dna2 nuclease-helicase structure, mechanism and regulation by Rpa
The Dna2 nuclease-helicase maintains genomic integrity by processing DNA double-strand breaks, Okazaki fragments and stalled replication forks. Dna2 requires ssDNA ends, and is dependent on the ssDNA-binding protein Rpa, which controls cleavage polarity. Here we present the 2.3 Å structure of intact...
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| Pubblicato in: | eLife |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4716839/ https://ncbi.nlm.nih.gov/pubmed/26491943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09832 |
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