Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients

CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) are increased in patients with chronic hepatitis C, which may contribute to the sustained suppression of hepatitis C virus (HCV)-specific T-cell responses and viral persistence in HCV-infected individuals. We postulated that HCV core protein (HCVc) di...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Immunol
Prif Awduron: Zhai, Naicui, Chi, Xiumei, Li, Tianyang, Song, Hongxiao, Li, Haijun, Jin, Xia, Crispe, Ian Nicholas, Su, Lishan, Niu, Junqi, Tu, Zhengkun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716623/
https://ncbi.nlm.nih.gov/pubmed/25531392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2014.119
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