TrkB Gene Therapy by Adeno-Associated Virus Enhances Recovery after Cervical Spinal Cord Injury

Unilateral cervical spinal cord hemisection at C2 (C2SH) interrupts descending bulbospinal inputs to phrenic motoneurons, paralyzing the diaphragm muscle. Recovery after C2SH is enhanced by brain derived neurotrophic factor (BDNF) signaling via the tropomyosin-related kinase subtype B (TrkB) recepto...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Martínez-Gálvez, Gabriel, Zambrano, Juan M., Diaz Soto, Juan C., Zhan, Wen-Zhi, Gransee, Heather M., Sieck, Gary C., Mantilla, Carlos B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715974/
https://ncbi.nlm.nih.gov/pubmed/26607912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2015.11.007
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