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Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis
Ubiquinone (UQ) is implicated in mitochondrial electron transport, superoxide generation, and as a membrane antioxidant. Here we present a mouse model in which UQ biosynthesis can be interrupted and partially restored at will. Global loss of UQ leads to gradual loss of mitochondrial function, gradua...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715896/ https://ncbi.nlm.nih.gov/pubmed/25744659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7393 |
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