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Blockade of Endothelial Growth Factor, Angiopoietin-2, Reduces Indices of ARDS and Mortality in Mice Resulting from the Dual-Insults of Hemorrhagic Shock and Sepsis

We have demonstrated hemorrhagic shock “priming” for the development of indirect (i)ARDS in mice following subsequent septic challenge and show pathology characteristic of patients with iARDS, including increased lung micro-vascular permeability and arterial PO(2)/FI0(2) reduced to levels comparable...

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Bibliographic Details
Published in:Shock
Main Authors: Lomas-Neira, Joanne L., Heffernan, Daithi S., Ayala, Alfred, Monaghan, Sean F.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715730/
https://ncbi.nlm.nih.gov/pubmed/26529660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000499
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