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α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage
BACKGROUND: ABT-126 is a novel, safe and well-tolerated α7 nicotinic receptor agonist in a Phase 2 Alzheimer's disease study. Here we test the antidyskinetic effect of ABT-126 in MPTP-treated squirrel monkeys with moderate and more severe nigrostriatal damage. METHODS: Monkeys (n=21, Set 1) wer...
Bewaard in:
| Gepubliceerd in: | Mov Disord |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4715565/ https://ncbi.nlm.nih.gov/pubmed/26573698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.26453 |
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