Myeloid-Derived Tissue-Type Plasminogen Activator Promotes Macrophage Motility through FAK, Rac1, and NF-κB Pathways

Macrophage accumulation is one of the hallmarks of progressive kidney disease. Tissue-type plasminogen activator (tPA) is known to promote macrophage infiltration and renal inflammation during chronic kidney injury. However, the underlying mechanism remains largely unknown. We examined the role of t...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Lin, Ling, Jin, Yang, Mars, Wendy M., Reeves, W. Brian, Hu, Kebin
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2014
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715214/
https://ncbi.nlm.nih.gov/pubmed/25131752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.013
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