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Tissue Plasminogen Activator Activates NF-κB through a Pathway Involving Annexin A2/CD11b and Integrin-Linked Kinase

NF-κB activation is central to the initiation and progression of inflammation, which contributes to the pathogenesis of CKD. Tissue plasminogen activator (tPA) modulates the NF-κB pathway, but the underlying mechanism remains unknown. We investigated the role of tPA signaling in macrophage NF-κB act...

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Detalhes bibliográficos
Main Authors: Lin, Ling, Wu, Chuanyue, Hu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402285/
https://ncbi.nlm.nih.gov/pubmed/22677557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011111123
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