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Hijacking leucyl-tRNA synthetase to amino acid-dependent regulation of TORC1

TORC1 activity in all eukaryotes is dependent on amino acids availability. However, the mechanism through which TORC1 senses amino acids is still a mystery unfolding like a detective story. Two new studies, implicate leucyl-tRNA synthetase in this evolving story.

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Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Segev, Nava, Hay, Nissim
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714921/
https://ncbi.nlm.nih.gov/pubmed/22500735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.028
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