Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway

AIM: SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats. However, the effect of SB-710411 on myocardial ischemia-reperfusion (I/R) injury is unclear. The present study was de...

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Bibliographic Details
Published in:PLoS One
Main Authors: Luo, Sheng-Yong, Chen, Shuo, Qin, Yi-De, Chen, Zhi-Wu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714846/
https://ncbi.nlm.nih.gov/pubmed/26771557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146094
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