Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells

Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical transient receptor potential (TRPC) 1 proteins in vascular smooth muscle cells (VSMCs), which contribute to important cellular functions. We have previously shown that PKC is obligat...

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Bibliographic Details
Published in:FASEB J
Main Authors: Shi, Jian, Miralles, Francesc, Birnbaumer, Lutz, Large, William A., Albert, Anthony P.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2016
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714548/
https://ncbi.nlm.nih.gov/pubmed/26467792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-280271
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