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Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity

Phospholipids (PLs) are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog-1 (LRH-1), which has evolved a novel allosteric pathway to support appropriate interaction with co-regulators depending on ligand status. LRH-1 plays an important role in controlling lipid and ch...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Musille, Paul M., Kossmann, Bradley R., Kohn, Jeffrey A., Ivanov, Ivaylo, Ortlund, Eric A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714224/
https://ncbi.nlm.nih.gov/pubmed/26553876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662874
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