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Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity
Phospholipids (PLs) are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog-1 (LRH-1), which has evolved a novel allosteric pathway to support appropriate interaction with co-regulators depending on ligand status. LRH-1 plays an important role in controlling lipid and ch...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4714224/ https://ncbi.nlm.nih.gov/pubmed/26553876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662874 |
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