Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules contribute to the stimulatory activity. QS-21 is a defined, highly purified, and soluble saponin adjuvant currently used in licensed and explorator...

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Foilsithe in:J Biol Chem
Main Authors: Marty-Roix, Robyn, Vladimer, Gregory I., Pouliot, Kimberly, Weng, Dan, Buglione-Corbett, Rachel, West, Kim, MacMicking, John D., Chee, Jonathan D., Wang, Shixia, Lu, Shan, Lien, Egil
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714196/
https://ncbi.nlm.nih.gov/pubmed/26555265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683011
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