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Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2

CARMILs regulate capping protein (CP), a critical determinant of actin assembly and actin-based cell motility. Vertebrates have three conserved CARMIL genes with distinct functions. In migrating cells, CARMIL2 is important for cell polarity, lamellipodial assembly, ruffling, and macropinocytosis. In...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lanier, M. Hunter, McConnell, Patrick, Cooper, John A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714192/
https://ncbi.nlm.nih.gov/pubmed/26578515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676882
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