Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction. In DCs, endogenous TRIM5α accumulates in nuclear bodie...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Portilho, Débora M., Fernandez, Juliette, Ringeard, Mathieu, Machado, Anthony K., Boulay, Aude, Mayer, Martha, Müller-Trutwin, Michaela, Beignon, Anne-Sophie, Kirchhoff, Frank, Nisole, Sébastien, Arhel, Nathalie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713866/
https://ncbi.nlm.nih.gov/pubmed/26748714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.039
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