Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

During retroviral infection, viral capsids are subject to restriction by the cellular factor TRIM5α. Here, we show that dendritic cells (DCs) derived from human and non-human primate species lack efficient TRIM5α-mediated retroviral restriction. In DCs, endogenous TRIM5α accumulates in nuclear bodie...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Portilho, Débora M., Fernandez, Juliette, Ringeard, Mathieu, Machado, Anthony K., Boulay, Aude, Mayer, Martha, Müller-Trutwin, Michaela, Beignon, Anne-Sophie, Kirchhoff, Frank, Nisole, Sébastien, Arhel, Nathalie J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713866/
https://ncbi.nlm.nih.gov/pubmed/26748714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.039
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