Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells

The AXL receptor tyrosine kinase is frequently overexpressed in cancers and is important in cancer invasion/metastasis and chemoresistance. Here, we demonstrate a regulatory feedback loop between AXL and microRNA (miRNA) at the post-transcriptional level. Both the GAS6-binding domain and the kinase...

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Veröffentlicht in:RNA
Hauptverfasser: Cho, Chun-Yu, Huang, Jhy-Shrian, Shiah, Shine-Gwo, Chung, Shih-Ying, Lay, Jong-Ding, Yang, Ya-Yu, Lai, Gi-Ming, Cheng, Ann-Lii, Chen, Li-Tzong, Chuang, Shuang-En
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712679/
https://ncbi.nlm.nih.gov/pubmed/26667302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.052571.115
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