Orexin Receptor Antagonism Improves Sleep and Reduces Seizures in Kcna1-null Mice

STUDY OBJECTIVE: Comorbid sleep disorders occur in approximately one-third of people with epilepsy. Seizures and sleep disorders have an interdependent relationship where the occurrence of one can exacerbate the other. Orexin, a wake-promoting neuropeptide, is associated with sleep disorder symptoms...

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Dettagli Bibliografici
Pubblicato in:Sleep
Autori principali: Roundtree, Harrison M., Simeone, Timothy A., Johnson, Chaz, Matthews, Stephanie A., Samson, Kaeli K., Simeone, Kristina A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Associated Professional Sleep Societies, LLC 2016
Soggetti:
Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712395/
https://ncbi.nlm.nih.gov/pubmed/26446112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.5444
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