Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respirator...

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Detaylı Bibliyografya
Asıl Yazarlar: Simeone, Kristina A, Matthews, Stephanie A, Samson, Kaeli K, Simeone, Timothy A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990438/
https://ncbi.nlm.nih.gov/pubmed/24270080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2013.11.005
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