Identification of miR-148a as a novel regulator of cholesterol metabolism

The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL-cholesterol (LDL-C). While the transcriptional regulation of LDLR is well-characterized, the post-transcriptional mechanisms which govern LDLR expression are just beginning to emerge. Here, we devel...

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Veröffentlicht in:Nat Med
Hauptverfasser: Goedeke, Leigh, Rotllan, Noemi, Canfrán-Duque, Alberto, Aranda, Juan F., Ramírez, Cristina M., Araldi, Elisa, Lin, Chin-Sheng, Anderson, Norma N., Wagschal, Alexandre, de Cabo, Rafael, Horton, Jay D., Lasunción, Miguel A., Näär, Anders M., Suárez, Yajaira, Fernández-Hernando, Carlos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711995/
https://ncbi.nlm.nih.gov/pubmed/26437365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3949
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