MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic instability; therefore, we determined DNA copy numb...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Genet
Päätekijät: Dalla Rosa, Ilaria, Cámara, Yolanda, Durigon, Romina, Moss, Chloe F., Vidoni, Sara, Akman, Gokhan, Hunt, Lilian, Johnson, Mark A., Grocott, Sarah, Wang, Liya, Thorburn, David R., Hirano, Michio, Poulton, Joanna, Taylor, Robert W., Elgar, Greg, Martí, Ramon, Voshol, Peter, Holt, Ian J., Spinazzola, Antonella
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711891/
https://ncbi.nlm.nih.gov/pubmed/26760297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005779
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia