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Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides

[Image: see text] Cyclic peptides have great potential as therapeutic agents and research tools. However, their applications against intracellular targets have been limited, because cyclic peptides are generally impermeable to the cell membrane. It was previously shown that fusion of cyclic peptides...

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Publié dans:ACS Comb Sci
Auteurs principaux: Trinh, Thi B., Upadhyaya, Punit, Qian, Ziqing, Pei, Dehua
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2015
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710893/
https://ncbi.nlm.nih.gov/pubmed/26645887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00164
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