Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Increasing evidence supports a role of neuroinflammation in the pathogenesis of Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway whereby Aβ acts as an upstream activator of astroglial nuclear factor kappa B (NF-κB), leading to the release of complement C3, whi...

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Vydáno v:J Neurosci
Hlavní autoři: Lian, Hong, Litvinchuk, Alexandra, Chiang, Angie C.-A., Aithmitti, Nadia, Jankowsky, Joanna L., Zheng, Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710776/
https://ncbi.nlm.nih.gov/pubmed/26758846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2117-15.2016
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