Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study

5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfat...

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Vydáno v:Arch Toxicol
Hlavní autoři: Sachse, Benjamin, Meinl, Walter, Sommer, Yasmin, Glatt, Hansruedi, Seidel, Albrecht, Monien, Bernhard H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2014
Témata:
Toxicokinetics and Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710668/
https://ncbi.nlm.nih.gov/pubmed/25370010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-014-1392-6
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