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Rational Redesign of the 4-Chlorobenzoate Binding Site of 4-Chlorobenzoate: Coenzyme A Ligase for Expanded Substrate Range()

Environmental aromatic acids are transformed to chemical energy in bacteria that possess the requisite secondary pathways. Some of these pathways rely on the activation of the aromatic acid by coenzyme A (CoA) thioesterification catalyzed by an aromatic acid: CoA ligase. Adaptation of such pathways...

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Pubblicato in:Biochemistry
Autori principali: Wu, Rui, Reger, Albert S., Cao, Jian, Gulick, Andrew M., Dunaway-Mariano, Debra
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710512/
https://ncbi.nlm.nih.gov/pubmed/18027984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701609w
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