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Engineering of stable and fast-folding sequences of model proteins.

The statistical mechanics of protein folding implies that the best-folding proteins are those that have the native conformation as a pronounced energy minimum. We show that this can be obtained by proper selection of protein sequences and suggest a simple practical way to find these sequences. The s...

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Detalles Bibliográficos
Main Authors: Shakhnovich, E I, Gutin, A M
Formato: Artigo
Idioma:Inglês
Publicado: 1993
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC47103/
https://ncbi.nlm.nih.gov/pubmed/8346235
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