Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

Protective immunoglobulin A (IgA) responses to oral antigens are usually orchestrated by gut dendritic cells (DCs). Here, we show that lung CD103(+) and CD24(+)CD11b(+) DCs induced IgA class-switch recombination (CSR) by activating B cells through T cell–dependent or –independent pathways. Compared...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Ruane, Darren, Chorny, Alejo, Lee, Haekyung, Faith, Jeremiah, Pandey, Gaurav, Shan, Meimei, Simchoni, Noa, Rahman, Adeeb, Garg, Aakash, Weinstein, Erica G., Oropallo, Michael, Gaylord, Michelle, Ungaro, Ryan, Cunningham-Rundles, Charlotte, Alexandropoulos, Konstantina, Mucida, Daniel, Merad, Miriam, Cerutti, Andrea, Mehandru, Saurabh
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710201/
https://ncbi.nlm.nih.gov/pubmed/26712806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150567
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares