Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

Protective immunoglobulin A (IgA) responses to oral antigens are usually orchestrated by gut dendritic cells (DCs). Here, we show that lung CD103(+) and CD24(+)CD11b(+) DCs induced IgA class-switch recombination (CSR) by activating B cells through T cell–dependent or –independent pathways. Compared...

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Vydáno v:J Exp Med
Hlavní autoři: Ruane, Darren, Chorny, Alejo, Lee, Haekyung, Faith, Jeremiah, Pandey, Gaurav, Shan, Meimei, Simchoni, Noa, Rahman, Adeeb, Garg, Aakash, Weinstein, Erica G., Oropallo, Michael, Gaylord, Michelle, Ungaro, Ryan, Cunningham-Rundles, Charlotte, Alexandropoulos, Konstantina, Mucida, Daniel, Merad, Miriam, Cerutti, Andrea, Mehandru, Saurabh
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710201/
https://ncbi.nlm.nih.gov/pubmed/26712806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150567
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