Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus

BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated. Immune cells have estrogen receptors (ERs), i.e., ERα and ERβ, that...

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Detalhes bibliográficos
Publicado no:Biol Sex Differ
Main Authors: Maselli, Angela, Conti, Fabrizio, Alessandri, Cristiano, Colasanti, Tania, Barbati, Cristiana, Vomero, Marta, Ciarlo, Laura, Patrizio, Mario, Spinelli, Francesca Romana, Ortona, Elena, Valesini, Guido, Pierdominici, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709986/
https://ncbi.nlm.nih.gov/pubmed/26759713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-016-0057-y
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