Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus

BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated. Immune cells have estrogen receptors (ERs), i.e., ERα and ERβ, that...

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Библиографические подробности
Опубликовано в: :Biol Sex Differ
Главные авторы: Maselli, Angela, Conti, Fabrizio, Alessandri, Cristiano, Colasanti, Tania, Barbati, Cristiana, Vomero, Marta, Ciarlo, Laura, Patrizio, Mario, Spinelli, Francesca Romana, Ortona, Elena, Valesini, Guido, Pierdominici, Marina
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709986/
https://ncbi.nlm.nih.gov/pubmed/26759713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-016-0057-y
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