Endothelium-Independent Hypoxic Contraction Is Prevented Specifically by Nitroglycerin via Inhibition of Akt Kinase in Porcine Coronary Artery

Objective. Hypoxia-induced sustained contraction of porcine coronary artery is endothelium-independent and mediated by PI3K/Akt/Rho kinase. Nitroglycerin (NTG) is a vasodilator used to treat angina pectoris and acute heart failure. The present study was to determine the role of NTG in hypoxia-induce...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Liu, Huixia, Li, Yanjing, An, Yuanming, He, Peixin, Wu, Liling, Gao, Yuansheng, Dou, Dou
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709768/
https://ncbi.nlm.nih.gov/pubmed/26839558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2916017
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