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Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries
BACKGROUND AND PURPOSE: The cGMP-dependent protein kinase (PKG) is a key enzyme for nitrovasodilator-induced vasodilation. The present study was to determine its role in nitrate tolerance. EXPERIMENTAL APPROACH: isolated porcine coronary arteries were incubated for 24 h with nitroglycerin (NTG) and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2241782/ https://ncbi.nlm.nih.gov/pubmed/18037907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707600 |
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