The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

INTRODUCTION: Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine associated with acute and chronic inflammatory disorders and corticosteroid insensitivity. Its expression in the airways of patients with chronic obstructive pulmonary disease (COPD), a relatively steroid insensit...

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Pubblicato in:PLoS One
Autori principali: Russell, Kirsty E., Chung, Kian Fan, Clarke, Colin J., Durham, Andrew L., Mallia, Patrick, Footitt, Joseph, Johnston, Sebastian L., Barnes, Peter J., Hall, Simon R., Simpson, Karen D., Starkey, Malcolm R., Hansbro, Philip M., Adcock, Ian M., Wiegman, Coen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709227/
https://ncbi.nlm.nih.gov/pubmed/26752192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146102
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