Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka ( Oryzias latipes ) embryo

The tumor suppressor protein, p53, plays pivotal roles in regulating apoptosis and proliferation in the embryonic and adult central nervous system (CNS) following neuronal injuries such as those induced by ionizing radiation. There is increasing evidence that p53 negatively regulates the self-renewa...

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Bibliographic Details
Published in:J Radiat Res
Main Authors: Yasuda, Takako, Kimori, Yoshitaka, Nagata, Kento, Igarashi, Kento, Watanabe-Asaka, Tomomi, Oda, Shoji, Mitani, Hiroshi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4708913/
https://ncbi.nlm.nih.gov/pubmed/26410759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jrr/rrv054
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