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Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development

Toxicity has been estimated to be responsible for the attrition of ~ 1/3 of drug candidates and is a major contributor to the high cost of drug development, particularly when not recognized until late in the clinical trials or post-marketing. The causes of drug toxicity can be organized in several w...

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Publicat a:Drug Metab Pharmacokinet
Autor principal: Guengerich, F. Peter
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707670/
https://ncbi.nlm.nih.gov/pubmed/20978361
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