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Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I

Erythropoietin (EPO) and insulin-like growth factor I (IGF-I) are cytokines that inhibit neuronal apoptosis. However, their maximal antiapoptotic effect, even at high concentrations, is observed only when neurons are pretreated for several hours before insult. Here we show that simultaneous administ...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Digicaylioglu, Murat, Garden, Gwenn, Timberlake, Sonia, Fletcher, Lauren, Lipton, Stuart A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC470763/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15210945/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403172101
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