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Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I

Erythropoietin (EPO) and insulin-like growth factor I (IGF-I) are cytokines that inhibit neuronal apoptosis. However, their maximal antiapoptotic effect, even at high concentrations, is observed only when neurons are pretreated for several hours before insult. Here we show that simultaneous administ...

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Autori principali: Digicaylioglu, Murat, Garden, Gwenn, Timberlake, Sonia, Fletcher, Lauren, Lipton, Stuart A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC470763/
https://ncbi.nlm.nih.gov/pubmed/15210945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403172101
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