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A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation
The retinoblastoma protein (pRB) is a critical regulator of cell proliferation and differentiation and an important tumor suppressor. In the G(1) phase of the cell cycle, pRB localizes to perinucleolar sites associated with lamin A/C intranuclear foci. Here, we examine pRB function in cells lacking...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC470734/ https://ncbi.nlm.nih.gov/pubmed/15210943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403250101 |
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