Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment

Although transcriptional induction of stress genes constitutes a major cellular defense program against a variety of stressors, posttranslational control directly regulating the activities of preexisting stress proteins provides a faster-acting alternative response. We propose that posttranslational...

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Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Zhang, Qiang, Bhattacharya, Sudin, Pi, Jingbo, Clewell, Rebecca A., Carmichael, Paul L., Andersen, Melvin E.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Contemporary Review: Impact of Posttranslational Stress Response Pathway Regulation on Safety Assessment Strategies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707198/
https://ncbi.nlm.nih.gov/pubmed/26408567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv130
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