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Tumor-priming Smoothened inhibitor enhances deposition and efficacy of cytotoxic nanoparticles in a pancreatic cancer model

Most pancreatic adenocarcinoma (PaCA) patients present with unresectable disease and benefit little from chemotherapy. Poor tumor perfusion and vascular permeability limit drug deposition. Previous work showed that smoothened inhibitors of hedgehog signaling (sHHI) promote neovascularization in spon...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Roy Chaudhuri, Tista, Straubinger, Ninfa L., Pitoniak, Rosemarie F., Hylander, Bonnie L., Repasky, Elizabeth A., Ma, Wen Wee, Straubinger, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707122/
https://ncbi.nlm.nih.gov/pubmed/26516158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0602
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