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Tumor-priming Smoothened inhibitor enhances deposition and efficacy of cytotoxic nanoparticles in a pancreatic cancer model
Most pancreatic adenocarcinoma (PaCA) patients present with unresectable disease and benefit little from chemotherapy. Poor tumor perfusion and vascular permeability limit drug deposition. Previous work showed that smoothened inhibitors of hedgehog signaling (sHHI) promote neovascularization in spon...
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| Publicado no: | Mol Cancer Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4707122/ https://ncbi.nlm.nih.gov/pubmed/26516158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0602 |
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