Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5

BACKGROUND: Therapeutic resistance and tumor recurrence are two major hurdles in the treatment of pancreatic ductal adenocarcinoma. Recent findings suggest that both of these attributes are associated with a small subset of pancreatic tumor initiating cancer stem cells (CSCs). Here, we demonstrate t...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Eng, Jason W.-L., Mace, Thomas A., Sharma, Rohit, Twum, Danielle Y. F., Peng, Peng, Gibbs, John F., Pitoniak, Rosemarie, Reed, Chelsey B., Abrams, Scott I., Repasky, Elizabeth A., Hylander, Bonnie L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915140/
https://ncbi.nlm.nih.gov/pubmed/27330806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0136-y
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