MFG-E8 Downregulates IL-17 Expression in Sepsis by Modulating STAT3 Activation

BACKGROUND: Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein with a known role in inflammation. In sepsis, interleukin-17 (IL-17) acts as a proinflammatory cytokine to exaggerate systemic inflammation. We hypothesize that MFG-E8 downregulates IL-17 expression...

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Dettagli Bibliografici
Pubblicato in:Surgery
Autori principali: Cen, Cindy, Aziz, Monowar, Yang, Weng-Lang, Nicastro, Jeffrey, Coppa, Gene F., Wang, Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707120/
https://ncbi.nlm.nih.gov/pubmed/26376757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2015.08.011
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