Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells

PURPOSE: This study investigates the combined effects of gemcitabine and trabectedin (ecteinascidin 743) in two pancreatic cancer cell lines and proposes a pharmacodynamic (PD) model to quantify their pharmacological interactions. METHODS: Effects of gemcitabine and trabectedin upon the pancreatic c...

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Vydáno v:Cancer Chemother Pharmacol
Hlavní autoři: Miao, Xin, Koch, Gilbert, Straubinger, Robert M., Jusko, William J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707118/
https://ncbi.nlm.nih.gov/pubmed/26604207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2907-4
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