Comparative analysis of novel complement-targeted inhibitors, miniFH, and the natural regulators Factor H and Factor H-like protein 1 reveal functional determinants of complement regulation

The serum proteins Factor H (FH), consisting of 20 complement control protein modules (CCPs), and its splice product Factor H-like protein 1 (FHL-1; consisting of CCPs 1–7) are major regulators of the alternative pathway (AP) of complement activation. The engineered version of FH, miniFH, contains o...

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Publicado no:J Immunol
Main Authors: Harder, Markus J., Anliker, Markus, Höchsmann, Britta, Simmet, Thomas, Huber-Lang, Markus, Schrezenmeier, Hubert, Ricklin, Daniel, Lambris, John D., Barlow, Paul N., Schmidt, Christoph Q.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707092/
https://ncbi.nlm.nih.gov/pubmed/26643478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501919
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