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Targeting ornithine decarboxylase by α-difluoromethylornithine inhibits tumor growth by impairing myeloid-derived suppressor cells
α-difluoromethylornithine (DFMO) is currently used in chemopreventive regimens primarily for its conventional direct anti-carcinogenesis activity. However, little is known about the effect of decarboxylase (ODC) inhibition by DFMO on antitumor immune responses. We showed here that pharmacologic bloc...
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| Publicado en: | J Immunol |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4707077/ https://ncbi.nlm.nih.gov/pubmed/26663722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500729 |
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