Proapoptotic Effect of Proteolytic Activation of Matrix Metalloproteinases by Streptococcus pyogenes Thiol Proteinase (Streptococcus Pyrogenic Exotoxin B)

Streptococcus pyogenes thiol proteinase, also known as streptococcal pyrogenic exotoxin B (SpeB), has been suggested to be a major virulence factor in S. pyogenes infection. SpeB was reported to induce apoptosis of host cells, but its mechanism of action is not yet fully understood. In this study, w...

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Bibliographic Details
Main Authors: Tamura, Fumio, Nakagawa, Rumiko, Akuta, Teruo, Okamoto, Shigefumi, Hamada, Shigeyuki, Maeda, Hiroshi, Kawabata, Shigetada, Akaike, Takaaki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC470685/
https://ncbi.nlm.nih.gov/pubmed/15271946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.8.4836-4847.2004
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