PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes

BACKGROUND: Mutation of PTEN-induced putative kinase 1 (PINK1) causes autosomal recessive early-onset Parkinson’s disease (PD). Despite of its ubiquitous expression in brain, its roles in non-neuronal cells such as neural stem cells (NSCs) and astrocytes were poorly unknown. RESULTS: We show that PI...

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Vydáno v:Mol Brain
Hlavní autoři: Choi, Insup, Choi, Dong-Joo, Yang, Haijie, Woo, Joo Hong, Chang, Mi-Yoon, Kim, Joo Yeon, Sun, Woong, Park, Sang-Myun, Jou, Ilo, Lee, Sang Hoon, Joe, Eun-Hye
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706723/
https://ncbi.nlm.nih.gov/pubmed/26746235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0186-6
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